Title of article
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor
Author/Authors
Nan-Horng Lin، نويسنده , , L.E. Wang، نويسنده , , Xilu Wang، نويسنده , , Gary T. Wang، نويسنده , , Jerry Cohen، نويسنده , , Wen-Zhen Gu، نويسنده , , Haiying Zhang، نويسنده , , Saul H. Rosenberg، نويسنده , , Hing L. Sham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
5057
To page
5062
Abstract
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities.
Keywords
FTI.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794926
Link To Document