Title of article
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction
Author/Authors
Kenneth M. Boy، نويسنده , , Jason M. Guernon، نويسنده , , Sing-Yuen Sit، نويسنده , , Kai Xie، نويسنده , , Piyasena Hewawasam*[1]، نويسنده , , Christopher G. Boissard، نويسنده , , Steven I. Dworetzky، نويسنده , , Joanne Natale، نويسنده , , Valentin K. Gribkoff، نويسنده , , Nicholas Lodge، نويسنده , , John E. Starrett Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5089
To page
5093
Abstract
A series of Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinone core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavernosum tissue strips confirms the potential to effect therapy for ED, the effect being maximal for the 3-amino-2-hydroxy thiol side chain.
Keywords
Maxi-K , BK , fax: +1 203 6777702 , Erectile dysfunction.* Corresponding author. Tel.: +1 203 677 6278 , e-mail: boyk@bms.com , Potassium channels
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794933
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