Title of article
Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.
Author/Authors
Rémy C. Lemoine، نويسنده , , Tomasz W. Glinka، نويسنده , , William J. Watkins، نويسنده , , Aesop Cho، نويسنده , , Jessie Yang، نويسنده , , Nadeem Iqbal، نويسنده , , Rajeshwar Singh، نويسنده , , Deidre Madsen، نويسنده , , Karen Lolans، نويسنده , , Olga Lomovskaya، نويسنده , , Uma Oza، نويسنده , , Michael N. Dudley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5127
To page
5131
Abstract
The discovery of a series of quinazolinone-based fungal efflux pump inhibitors by high-throughput screening for potentiation of fluconazole in C. albicans is described. Attempts to improve the aqueous solubility of screening hits led to the discovery of an analog with greatly improved physical properties and activity against clinically-relevant Candida spp.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794941
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