Title of article
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
Author/Authors
John G. Cumming، نويسنده , , Caroline L. McKenzie، نويسنده , , Stuart G. Bowden، نويسنده , , Douglas Campbell، نويسنده , , David J. Masters، نويسنده , , Jason Breed، نويسنده , , Philip J. Jewsbury، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
5389
To page
5394
Abstract
SAR studies led to the identification of 4-(3-benzoylamino-6-methyl-anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo.
Keywords
p38 MAP kinase inhibitors.* Corresponding author. Tel.: +44 1625 517755 , e-mail: john.cumming@astrazeneca.com , fax: +44 1625510823
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794991
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