Title of article
Synthesis of small molecule CDC25 phosphatases inhibitors
Author/Authors
Marie-Odile Contour-Galcéra، نويسنده , , Olivier Lavergne، نويسنده , , Marie-Christine Brezak، نويسنده , , Bernard Ducommun، نويسنده , , Grégoire Prévost، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5809
To page
5812
Abstract
A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target
Keywords
Dual specificity phosphatases inhibitor , Cdc25 inhibitor , Antiproliferative agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795072
Link To Document