Title of article
Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents
Author/Authors
Patrizia Cal?، نويسنده , , Lars N?rum، نويسنده , , Seema Mukhija، نويسنده , , Anders Hjelmencrantz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5997
To page
6000
Abstract
A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
Keywords
Peptide deformylase , e-mail: pca@combio.biz , fax: +45 70222367 , inhibitors , Antibacterial.* Corresponding author. Tel.: +45 70222365
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795112
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