• Title of article

    N-Hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity

  • Author/Authors

    Jiyong Lee، نويسنده , , Joong Sup Shim، نويسنده , , Sun-Ah Jung، نويسنده , , Seung-Taek Lee، نويسنده , , Ho Jeong Kwon، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    3
  • From page
    181
  • To page
    183
  • Abstract
    In the course of our screening, N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide (1), which contains a metal-chelating hydroxamate group, has been identified as a potent inhibitor of aminopeptidase N (APN, EC 3.4.11.2). Compound 1 potently inhibited APN activity with a Ki value of 3.5 μM. It also inhibited the basic fibroblast growth-factor-induced invasion of bovine aortic endothelial cells at low micromolar concentrations.
  • Keywords
    aminopeptidase N , angiogenesis , metalloproteinase
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795175

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795175