Title of article
Trypanocidal activity of (−)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi
Author/Authors
Vanessa A. de Souza، نويسنده , , Rosangela da Silva، نويسنده , , Ana C. Pereira، نويسنده , , Vanessa de A. Royo، نويسنده , , Juliana Saraiva، نويسنده , , Marisa Montanheiro، نويسنده , , Gustavo H.B. de Souza، نويسنده , , Ademar A. da Silva Filho، نويسنده , , Marcella D. Grando، نويسنده , , Paulo M. Donate، نويسنده , , Jairo K. Bastos، نويسنده , , Sérgio Albuquerque، نويسنده , , Marcio L.A. e Silva، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
303
To page
307
Abstract
Five (−)-cubebin derivative compounds, (−)-O-acetyl cubebin (3), (−)-O-benzyl cubebin (4), (−)-O-(N,N-dimethylaminoethyl)-cubebin (5), (−)-hinokinin (6) and (−)-6,6′-dinitrohinokinin (7), previously synthesised by our research group, were evaluated on in vitro assay against free amastigote forms of Trypanosoma cruzi, the asogic agent of Chagas’ disease. It was observed that 6 was the most active compound (IC50 = 0.7 μM), and that 4 and 5 displayed moderate activity against the parasite, giving IC50 values of 5.7 and 4.7 μM, respectively. In contrast, it was observed that compound 3 was inactive and that 7 displayed low activity with IC50 values of 1.5 × 104 and 95.3 μM, respectively.
Keywords
Amastigote forms , Lignans dibenzylbutyrolactones , Cubebin derivatives , Trypanocidal activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795197
Link To Document