Title of article
Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis
Author/Authors
Dmitry Zuev، نويسنده , , Jodi A. Michne، نويسنده , , Sokhom S. Pin، نويسنده , , Jie Zhang، نويسنده , , Matthew T. Taber، نويسنده , , Gene M. Dubowchik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
431
To page
434
Abstract
An efficient approach was developed to synthesize 2-(2,4,6-trichlorophenylamino)-4-trifluoromethyl-5-aminomethylthiazoles, corticotropin-releasing factor type 1 receptor (CRF1R) antagonists, by monoalkylation of amines with chloromethyl intermediate 5. The effect of variations in aminomethyl side chain of 6 on binding affinity is discussed.
Keywords
Corticotropin-releasing factor , depression , Anxiety , parallel synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795220
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