Title of article
Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides
Author/Authors
Kentaro Hashimoto، نويسنده , , Miyuki Tatsuta، نويسنده , , Mikayo Kataoka، نويسنده , , Kayo Yasoshima، نويسنده , , Yuka Shogase، نويسنده , , Makoto Shimazaki، نويسنده , , Takeshi Yura، نويسنده , , Yingfu Li، نويسنده , , Noriyuki Yamamoto ، نويسنده , , Jang B. Gupta، نويسنده , , Klaus Urbahns، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
799
To page
803
Abstract
A new class of benzimidazole-5-sulfonamides has been identified as nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Initial structure–activity relationships are presented resulting in compounds 19 and 28 with submicromolar dual functional activity on human and rat receptors.
Keywords
Small molecule , LHRH antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795290
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