Title of article
Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor
Author/Authors
Deborah A. Evrard، نويسنده , , Ping Zhou، نويسنده , , Soo Y. Yi، نويسنده , , Dahui Zhou، نويسنده , , Deborah L. Smith، نويسنده , , Kelly M. Sullivan، نويسنده , , Geoffrey A. Hornby، نويسنده , , Lee E. Schechter، نويسنده , , Terrance H. Andree، نويسنده , , Richard E. Mewshaw، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
911
To page
914
Abstract
Derivatives of the serotonin reuptake inhibitor 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine, in which serotonin 1A (5-HT1A) receptor pharmacophoric elements are incorporated, are reported. Analogs exhibiting affinity for both the serotonin transporter and the 5-HT1A receptor are described. Compounds containing 1-(4-indolyl)piperazine and 2-(1H-indol-4-yloxy)ethylamine are promising leads for further SAR studies.
Keywords
Serotonin , SSRI , 5-HT1A receptor antagonist , Antidepressant
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795308
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