Title of article
Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I
Author/Authors
Daisuke Kamiya، نويسنده , , Yuki Uchihata، نويسنده , , Eiko Ichikawa، نويسنده , , Kuniki Kato، نويسنده , , Kazuo Umezawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1111
To page
1114
Abstract
Suppression of resistance to anticancer drugs by COTC of glyoxalase I (GloI) inhibitor targeting intracellular glutathione (GSH) and GloI was studied. Depletion of the cellular GSH content and inhibition of GloI by COTC increased chemotherapy-mediated apoptosis in apoptosis-resistant pancreatic adenocarcinoma AsPC-1 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795346
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