Title of article
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics
Author/Authors
Chang-Hsing Liang، نويسنده , , Sulan Yao، نويسنده , , Yu-Hung Chiu، نويسنده , , Po Yee Leung، نويسنده , , Nicole Robert، نويسنده , , Jaime Seddon، نويسنده , , Pam Sears، نويسنده , , Chan-Kou Hwang، نويسنده , , Yoshi Ichikawa، نويسنده , , Alex Romero، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1307
To page
1310
Abstract
A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excellent in vitro antibacterial activities were demonstrated for ketolide analogues having the 6′-OBz-3′-dimethylamino-glucose and 6′-OBz-4′-deoxy-3′-dimethylamino-glucose substituents.
Keywords
Glycosylated , Ketolide , 2-Fluoro-ketolide , macrolide resistance
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795385
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