Title of article
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
Author/Authors
David R. Anderson، نويسنده , , Shridhar Hegde، نويسنده , , Emily Reinhard، نويسنده , , Leslie Gomez، نويسنده , , William F. Vernier، نويسنده , , National Chiao Tung University Chung Len Lee، نويسنده , , Shuang Liu، نويسنده , , Aruna Sambandam، نويسنده , , Patricia A. Snider، نويسنده , , Liaqat Masih، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1587
To page
1590
Abstract
A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported.
Keywords
MK-2 , kinase inhibitor , TNF?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795440
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