Title of article
18F-Labeled sufentanil for PET-imaging of μ-opioid receptors
Author/Authors
Gjermund Henriksen، نويسنده , , Stefan Platzer، نويسنده , , Andrea Hauser، نويسنده , , Frode Willoch، نويسنده , , Achim Berthele، نويسنده , , Markus Schwaiger، نويسنده , , Hans-Jürgen Wester، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1773
To page
1777
Abstract
The synthesis of an 18F-labeled sufentanil analogue with apparent high μ-opioid receptor selectivity is reported. Intravenous injection of N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-2-(±)-[18F]fluoropropan-amide in mice resulted in high brain uptake and a regional brain activity distribution corresponding to the μ-opioid receptor expression pattern. The developed ligand is a promising tracer for extended protocols in μ-opioid receptor mapping and quantitation with positron emission tomography.
Keywords
4-Anilidopiperidines , sufentanil , positron emission tomography , Fluorine-18 , Opioid receptor imaging
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795475
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