Title of article
Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018)
Author/Authors
Xiang-Yu Han، نويسنده , , He Liu، نويسنده , , Chun-He Liu، نويسنده , , Bo Wu، نويسنده , , Lan-Fu Chen، نويسنده , , Bo-Hua Zhong، نويسنده , , Keliang Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1979
To page
1982
Abstract
A practical diastereoselective synthetic method for 8018 enantiopure isomers is described. The intramolecular asymmetric epoxidation of mono-sulfonate 4 was applied for the execution of the synthesis of the key chiral building block for the first time. The isomers were obtained with 70–76% yields in 99–100% ee.
Keywords
Epoxidation , Isomers , Penehyclidine hydrochloride , asymmetric
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795514
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