Title of article
Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles
Author/Authors
Alireza Foroumadi، نويسنده , , Shirin Pournourmohammadi، نويسنده , , Fatemeh Soltani، نويسنده , , Mitra Asgharian-Rezaee، نويسنده , , Shahriar Dabiri، نويسنده , , Arsalan Kharazmi، نويسنده , , Abbas Shafiee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
1983
To page
1985
Abstract
A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a–d and 6a–j) were synthesized and evaluated against Leishmania major promastigotes using 3H-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC50 = 0.1 μM).
Keywords
1 , 3 , 4-thiadiazole , Nitrofuran , Nitrothiophene , Leishmanicidal activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795515
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