Title of article
A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor
Author/Authors
David V. Smil، نويسنده , , Fabio E.S. Souza، نويسنده , , Alex G. Fallis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2057
To page
2060
Abstract
Magnesium mediated carbometalation (Grignard addition) to appropriate propargyl alcohols to synthesize a cross-section of variably substituted α,β-unsaturated γ-sultines is described. Thio-rofecoxib, a selective COX-2 inhibitor (12), is synthesized by this method and its IC50, μM COX-1 and COX-2 inhibition, and whole blood stability values reported.
Keywords
Propargyl alcohols , Carbometalation , Sultines , COX-2 inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795530
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