Title of article
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts
Author/Authors
B. Narasimhulu Naidu، نويسنده , , Margaret E. Sorenson، نويسنده , , Joanne J. Bronson، نويسنده , , Michael J. Pucci، نويسنده , , Junius M. Clark، نويسنده , , Yasutsugu Ueda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2069
To page
2072
Abstract
The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4–20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity.
Keywords
Nocathiacin I , Thiol-Michael adducts , Antibacterial activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795533
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