Title of article
A fluorimetric assay for the spontaneous release of an N7-alkylguanine residue from duplex DNA
Author/Authors
Ekaterina Shipova، نويسنده , , Kent S. Gates، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
2111
To page
2113
Abstract
A fluorimetric assay for monitoring depurination of the N7-alkylguanine adduct derived from the anticancer natural product leinamycin is described. This general approach could potentially provide the foundation for a high throughput assay that detects DNA-alkylating agents or a convenient continuous fluorimetric assay for base excision repair enzymes.
Keywords
DNA alkylation , Antitumor agent , Depurination , natural product , Nucleic acid chemistry
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795542
Link To Document