Title of article
Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles
Author/Authors
Ashoke Sharon، نويسنده , , Ramendra Pratap، نويسنده , , Priti Tiwari، نويسنده , , Arvind Srivastava، نويسنده , , P.R. Maulik، نويسنده , , Vishnu Ji Ram، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
2115
To page
2117
Abstract
A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a–h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague–Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor γ agonistic property, but none of them displayed any significant activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795543
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