Title of article
A structural screening approach to ketoamide-based inhibitors of cathepsin K
Author/Authors
David G. Barrett، نويسنده , , John G. Catalano، نويسنده , , David N. Deaton، نويسنده , , Stacey T. Long، نويسنده , , Robert B. McFadyen، نويسنده , , Aaron B. Miller، نويسنده , , Larry R. Miller، نويسنده , , Kevin J. Wells-Knecht، نويسنده , , Lois L. Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2209
To page
2213
Abstract
Several novel ketoamide-based inhibitors of cathepsin K have been identified. Starting from a modestly potent inhibitor, structural screening of P2 elements led to 100-fold enhancements in inhibitory activity. Modifications to one of these leads resulted in an orally bioavailable cathepsin K inhibitor.
Keywords
Ketoamide , Cathepsin K , Structural screening , Cysteine protease inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795559
Link To Document