Title of article
Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors
Author/Authors
Brad O. Buckman، نويسنده , , Yuo-Ling Chou، نويسنده , , Meg McCarrick، نويسنده , , Amy Liang، نويسنده , , Dao Lentz، نويسنده , , Raju Mohan، نويسنده , , Michael M. Morrissey، نويسنده , , Kenneth J. Shaw، نويسنده , , Lan Trinh، نويسنده , , David R. Light، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2249
To page
2252
Abstract
Reductive amination followed by acylation of polymer-linked formyl aryl amidines generate combinatorial libraries of aryl amidines 8–13. Potent small molecule naphthylamidine inhibitors 12 (Ki < 100 nM) of FVIIa/TF have been discovered and their activity against other serine proteases in the coagulation cascade is reported.
Keywords
solid-phase synthesis , Naphthylamidines , Factor VIIa/tissue factor inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795567
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