Title of article
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships
Author/Authors
Sergio A. Alonso De Diego، نويسنده , , Pilar Mu?oz، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده , , Rosario Herranz، نويسنده , , Mercedes Mart?n-Mart?nez، نويسنده , , Edurne Cenarruzabeitia، نويسنده , , Diana Frechilla، نويسنده , , Joaqu?n Del R?o، نويسنده , , M. Luisa Jimeno، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2279
To page
2283
Abstract
A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
Keywords
Gly-Pro-Glu (GPE) , neuroprotection , Structure–activity relationships
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795573
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