Title of article
Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Author/Authors
Rachel M. Williamson، نويسنده , , Amy L. Pietersma، نويسنده , , Geoffrey B. Jameson، نويسنده , , Emily J. Parker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2339
To page
2342
Abstract
Racemic 2-deoxyerythrose 4-phosphate was synthesized and one enantiomer of this compound was found to be a substrate for Escherichia coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, the first enzyme of the shikimate pathway. When the reaction was carried out in deuterium oxide, an enzyme-catalyzed regio- and stereoselective incorporation of deuterium into the product was observed.
Keywords
Shikimate , Erythrose 4-phosphate , 3-Deoxy-d-arabino-heptulosonate 7-phosphate , Deoxyerythrose 4-phosphate
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795585
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