Title of article
Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002)
Author/Authors
Shoukath M. Ali، نويسنده , , Abdul R. Khan، نويسنده , , Moghis U. Ahmad، نويسنده , , Paul Chen، نويسنده , , Saifuddin Sheikh، نويسنده , , Imran Ahmad، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2571
To page
2574
Abstract
A novel gemcitabine–lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar®.
Keywords
Gemcitabine , cardiolipin , Lipid–nucleoside conjugate , prodrug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795628
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