Synthesis and biological studies of yohimbine derivatives on human α2C-adrenergic receptors

A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human α2C-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for α2C-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.