Title of article
Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines
Author/Authors
Xiangshu Xiao، نويسنده , , Zehong Miao، نويسنده , , Smitha Antony، نويسنده , , Yves Pommier، نويسنده , , Mark Cushman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2795
To page
2798
Abstract
Dihydroindenoisoquinolines are analogs of cytotoxic indenoisoquinoline topoisomerase I (Top1) inhibitors, exhibiting potent cytotoxicity but weak inhibitory activity toward Top1. Through COMPARE analysis, cytotoxicity studies in Top1-deficient cells, chemical synthesis and biological evaluation of methylated dihydroindenoisoquinoline 5, we demonstrated that dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines in cancer cells.
Keywords
Indenoisoquinoline , Dihydroindenoisoquinoline , antitumor , Prodrug. , topoisomerase I
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795673
Link To Document