Title of article
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
Author/Authors
Tae-Hyuk Kim، نويسنده , , Kamil Kuca، نويسنده , , Daniel Jun، نويسنده , , Young-Sik Jung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2914
To page
2917
Abstract
New bis-pyridinium oxime reactivators connected with a CH2CH2OCH2CH2 linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10−4 M.
Keywords
Organophosphorus nerve agents , Bis-pyridinium oxime reactivators , inhibition , Acetylcholinesterase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795698
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