Title of article
Nitrone derivatives of trolox as neuroprotective agents
Author/Authors
Gy?rgy T. Balogh، نويسنده , , Krisztina Vukics، نويسنده , , ?rp?d K?ncz?l، نويسنده , , ?gnes Kis-Varga، نويسنده , , Anik? Gere، نويسنده , , J?nos Fischer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3012
To page
3015
Abstract
Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.
Keywords
neuroprotection , Free radical scavenging , Lipid peroxidation , Permanent middle cerebral artery occlusion , nitrone , Trolox
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795716
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