Title of article
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones
Author/Authors
Robert E. McDevitt، نويسنده , , Michael S. Malamas، نويسنده , , Eric S. Manas، نويسنده , , Rayomand J. Unwalla and William S. Somers، نويسنده , , Zhang B. Xu، نويسنده , , Chris P. Miller، نويسنده , , Heather A. Harris، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
3137
To page
3142
Abstract
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERβ and ERα are described. Several compounds exhibited high potency and moderate selectivity for the ERβ receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795742
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