• Title of article

    Novel phomactin analogues as PAF receptor ligands

  • Author/Authors

    William P.D. Goldring، نويسنده , , Stephen P.H. Alexander، نويسنده , , David A. Kendall، نويسنده , , Gerald Pattenden، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    4
  • From page
    3263
  • To page
    3266
  • Abstract
    A range of natural and unnatural phomactins, recently synthesised in our laboratory, were found to exhibit PAF antagonism with pIC50 values in the range 5.6–6.2. The variation in structural and stereochemical features between the phomactins was found to have only a modest effect on the inhibition of binding of PAF to its human platelet receptors.
  • Keywords
    PAF , Antagonist , diterpene , Phomactin , platelet activating factor
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795768

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795768