Title of article
Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents
Author/Authors
Masao Yoshida، نويسنده , , Jun-ichiro Hayakawa، نويسنده , , Noriyuki Hayashi، نويسنده , , Toshinori Agatsuma، نويسنده , , Youko Oda، نويسنده , , Fumie Tanzawa، نويسنده , , Shiho Iwasaki، نويسنده , , Kumiko Koyama، نويسنده , , Hidehiko Furukawa، نويسنده , , Shinichi Kurakata، نويسنده , , Yuichi Sugano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3328
To page
3332
Abstract
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
Keywords
Anticancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795783
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