Title of article
A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists
Author/Authors
Alberto Dordal، نويسنده , , Mike Lipkin، نويسنده , , Jackie Macritchie، نويسنده , , Josep Mas، نويسنده , , Adriana Port، نويسنده , , Sally Rose، نويسنده , , Leonardo Salgado، نويسنده , , Vladimir Savic، نويسنده , , Wolfgang Schmidt، نويسنده , , Maria Teresa Serafini، نويسنده , , William Spearing، نويسنده , , Antoni Torrens Torrell، نويسنده , , Sandra Yeste، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
3679
To page
3684
Abstract
The metabolic stability of benzoxazinone derivatives, a potent series of NPY Y5 antagonists, has been investigated. This study resulted in the identification of the structural moieties prone to metabolic transformations and which strongly influenced the in vitro half-life. This provides opportunities to optimize the structure of this new class of NPY Y5 antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795859
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