Title of article
New α-methylene-γ-butyrolactones with antimycobacterial properties
Author/Authors
Minerva A. Hughes، نويسنده , , Jill M. McFadden، نويسنده , , Craig A. Townsend، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
3857
To page
3859
Abstract
The synthesis and antimycobacterial activity of a series of α-methylene-γ-butyrolactones based on the natural product protolichesterinic acid are described. Compounds 9–12 bearing an allylamide group at the C-4 position showed improved activity with MICs in the range of 6.25–12.5 μg/mL.
Keywords
Mycobacteria , butyrolactones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795894
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