Title of article
Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers
Author/Authors
Mingzhang Gao، نويسنده , , Kathy D. Miller، نويسنده , , George W. Sledge Jr، نويسنده , , Qi-Huang Zheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3865
To page
3869
Abstract
Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy-20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)-camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)-camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
Keywords
Tracer , topoisomerase I , cancer , Carbon-11-labeled camptothecin derivatives , Radiosynthesis , positron emission tomography
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795896
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