• Title of article

    Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

  • Author/Authors

    Steven P. Govek، نويسنده , , Céline Bonnefous، نويسنده , , John H. Hutchinson، نويسنده , , Theodore Kamenecka، نويسنده , , Jeffrey McQuiston، نويسنده , , Richard Pracitto، نويسنده , , Lucy X. Zhao، نويسنده , , Michael F. Gardner، نويسنده , , Joyce K. James، نويسنده , , Lorrie P. Daggett، نويسنده , , Blake A. Rowe، نويسنده , , Herve Schaffhauser، نويسنده , , Linda J. Bristow، نويسنده , , Una C. Campbell، نويسنده , , Dana E. Rodriguez، نويسنده , , Jean-Michel Vernier، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    5
  • From page
    4068
  • To page
    4072
  • Abstract
    Metabotropic glutamate receptor 2 (mGluR2) has been implicated in a variety of CNS disorders, including schizophrenia. Disclosed herein is the development of a new series of allosteric potentiators of mGluR2. Structure–activity relationship studies in conjunction with pharmacokinetic data led to the discovery of indole 5, which is active in an animal model for schizophrenia.
  • Keywords
    metabotropic glutamate receptor , Schizophrenia , Allosteric potentiator , mGluR2 , mGlu2
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795935

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795935