Title of article
Identification of potent and selective MMP-13 inhibitors
Author/Authors
Junjun Wu، نويسنده , , Thomas S. Rush III، نويسنده , , Rajeev Hotchandani، نويسنده , , Xuemei Du، نويسنده , , Mary Geck، نويسنده , , Elisabeth Collins، نويسنده , , Zhang-Bao Xu، نويسنده , , Jerry Skotnicki، نويسنده , , Jeremy I. Levin، نويسنده , , Frank E. Lovering، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4105
To page
4109
Abstract
A potent, selective series of MMP-13 inhibitors has been derived from a weak (3.2 μM) inhibitor that did not bear a zinc chelator. Structure-based drug design strategies were employed to append a Zn-chelating group to one end of the molecule and functionality to enhance selectivity to the other. A compound from this series demonstrated rat oral bioavailability and efficacy in a bovine articular cartilage explant model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795942
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