Title of article
Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues
Author/Authors
David Y.W. Lee، نويسنده , , Minsheng He، نويسنده , , Leelakrishna Kondaveti، نويسنده , , Lee-Yuan Liu-Chen، نويسنده , , Zhongze Ma، نويسنده , , Yulin Wang، نويسنده , , Yong Chen، نويسنده , , Jianguo Li، نويسنده , , Cécile Béguin، نويسنده , , William A. Carlezon Jr، نويسنده , , Bruce Cohen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4169
To page
4173
Abstract
Salvinorin A is the most potent naturally occurring opioid agonist with a high selectivity and affinity for κ-opioid receptor. To explore its structure–activity relationships, modifications at the C(4) position have been studied and a series of salvinorin A derivatives were prepared. These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human κ-opioid receptor and several potent new agonists have been identified.
Keywords
Salvinorin A , ?-Opioid receptor , Neoclerodane diterpene , agonist , IN VITRO
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795951
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