Title of article
Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities
Author/Authors
Shinnosuke Hosoda، نويسنده , , Aya Tanatani، نويسنده , , Ken-ichi Wakabayashi، نويسنده , , Yusuke Nakano، نويسنده , , Hiroyuki Miyachi، نويسنده , , Kazuo Nagasawa، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4327
To page
4331
Abstract
Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.
Keywords
vitamin D3 , Androgen antagonist , Bisphenylmethane
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795986
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