Title of article
1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors
Author/Authors
Christopher D. Beadle، نويسنده , , John Boot، نويسنده , , Nicholas P. Camp، نويسنده , , Nancy Dezutter، نويسنده , , Jeremy Findlay، نويسنده , , Lorna Hayhurst، نويسنده , , John J. Masters، نويسنده , , Roberta Penariol، نويسنده , , Magnus W. Walter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
4432
To page
4437
Abstract
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
Keywords
Monoamine reuptake inhibitors , SAR , Norepinephrine , Quinolin-2-one , Pharmacophore , Selective norepinephrine reuptake inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796005
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