Title of article
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2′,2′-diphenylpropionoxymethyl)pyridinium
Author/Authors
Ji-Quan Wang، نويسنده , , Michael A. Miller، نويسنده , , Bruce H. Mock، نويسنده , , John C. Lopshire، نويسنده , , William J. Groh، نويسنده , , Douglas P. Zipes، نويسنده , , Gary D. Hutchins، نويسنده , , Qi-Huang Zheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4510
To page
4514
Abstract
A new AChE tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2′,2′-diphenylpropionoxymethyl)pyridinium ([11C]MDDP, [11C]1) has been synthesized in 40–65% radiochemical yield. Initial PET dynamic studies of [11C]MDDP in rat heart showed rapid heart uptake and blood pool clearance to give high-quality heart images. Blocking studies of [11C]MDDP with pretreatment drug neostigmine in rats found only minor reductions in rat heart [11C]MDDP retention. The results suggest that [11C]MDDP delineates the heart very clearly, and the uptakes of [11C]MDDP in rat heart might be related to non-specific binding.
Keywords
synthesis , positron emission tomography , heart , Acetylcholinesterase , 2?-diphenylpropionoxymethyl)pyridinium , Tracer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796022
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