Title of article
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
Author/Authors
Howard Sard، نويسنده , , Govindaraj Kumaran، نويسنده , , Cynthia Morency، نويسنده , , Bryan L. Roth، نويسنده , , Beth Ann Toth، نويسنده , , Ping He، نويسنده , , Louis Shuster، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4555
To page
4559
Abstract
An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT2C receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive–compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT2C agonists with applications for drug discovery.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796032
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