Title of article
8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity
Author/Authors
Jamie M. Singer، نويسنده , , Bridget M. Barr، نويسنده , , Linda L. Coughenour، نويسنده , , Tracy F. Gregory، نويسنده , , Michael A. Walters، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4560
To page
4563
Abstract
Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia.
Keywords
Dopamine , Atypical antipsychotics , Serotonin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796033
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