Title of article
The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: A potential strategy for targeting cancer cells
Author/Authors
Debra L. Mohler، نويسنده , , Thomas A. Shell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4585
To page
4588
Abstract
DNA strand scission is produced by the ambient light photolysis of CpFe(CO)2Ph and H2O2, a result that shows potential as a means of targeting tumors, due to the high levels of hydrogen peroxide in cancer cells. This cleavage process is dependent on the concentration of both CpFe(CO)2Ph and H2O2, and preliminary experiments implicate both carbon-centered radicals and reactive oxygen species.
Keywords
DNA cleavage , ROS , photolysis , Carbon radicals , hydrogen peroxide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796038
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