Title of article
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints
Author/Authors
Guohua Chu، نويسنده , , Minghua Gu، نويسنده , , Joel A. Cassel، نويسنده , , Serge Belanger، نويسنده , , Thomas M. Graczyk، نويسنده , , Robert N. DeHaven، نويسنده , , Nathalie Conway-James، نويسنده , , Mike Koblish، نويسنده , , Patrick J. Little، نويسنده , , Diane L. DeHaven-Hudkins، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
5114
To page
5119
Abstract
Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.
Keywords
analgesic , Kappa opioid receptor agonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796139
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