Title of article
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
Author/Authors
Patricia Melnyk، نويسنده , , Virginie Leroux، نويسنده , , Christian Sergheraert، نويسنده , , Philippe Grellier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
31
To page
35
Abstract
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.
Keywords
antimalarial , library , hydrazone , Iron chelator
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796306
Link To Document