Title of article
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility
Author/Authors
Hitoshi Ban، نويسنده , , Masami Muraoka، نويسنده , , Katsuhisa Ioriya، نويسنده , , Naohito Ohashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
44
To page
48
Abstract
4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed potent ACAT inhibitory activity and excellent oral efficacy.
Keywords
AACAT inhibitor , SMP-797 , A4-Phenyl-1 , 8-naphthyridin-2(1H)-on-3-yl ureas
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796309
Link To Document