Title of article
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Author/Authors
Raquel Pereira، نويسنده , , Claudine Gaudon، نويسنده , , Beatriz Iglesias، نويسنده , , Pierre Germain، نويسنده , , Hinrich Gronemeyer، نويسنده , , Angel R. de Lera، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
49
To page
54
Abstract
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARβ/δ agonist yet described, and equally selective analogs at the thiazole-C4 position.
Keywords
PPAR , thiazoles , Stille reactions , Suzuki reactions , Nuclear receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796310
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