Title of article
Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity
Author/Authors
Kelly McClure، نويسنده , , Michael Hack، نويسنده , , Liming Huang، نويسنده , , Clark Sehon، نويسنده , , Magda Morton، نويسنده , , Lina Li، نويسنده , , Terrance D. Barrett، نويسنده , , Nigel Shankley، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
72
To page
76
Abstract
High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free–Wilson) and non-additive SAR. This use of additive QSAR modeling in conjunction with combinatorial libraries represents a unique approach to the evaluation of SAR interactions between the variables of any combinatorial matrix.
Keywords
combinatorial , Additivity , Pyrazole , CCK1 , cholecystokinin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796315
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